I drove about 30k miles in one year between Detroit and Chicago. Sometimes, 3 times a week. I found as long as you keep you RPM below 2k, your doing good. I don't have the hills or grades like in PA but I found that at 18-19k RPM (around 63-64mph), I could get 26.7mpg. Now, I had a K&N airfilter and stock tires. No A/C running and it was warm and sunny. On a return trip, 26.0 but had rain and was cooler with some cross winds. City, slow take offs, and slow slowdowns before reaching a light neted me 17-18 city. It's hard to follow the same tatics in the city but highway, just don't be in a hurry and you can get some decent MPG. I normally got 22 but that was driving 75-80. Over 80, it doesn't matter, it's still not going to be good. The worst I got was 19 but conditions doesn't matter when it's that bad.
Now, since then, I've added full skids (except gas tank). Added KK-SL2's from JCR offraod

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roof rack with crossrails that I never take off, bug sheild and class III hiden-hitch with one of these stickingout the back

so, right now, I'm at 21hwy, 14city. I just got my 60k service done and had platnium plugs installed and the garage said it was burning a little rich. Throtle body was pretty dirty too. I know I'm getting better because I filled it up. drove 50 miles and I still show full (didn't fill up the neck either). I'll be happy with near the EPA rating. I need to burn through a few tanks before I get a good reading. Oh, and I have 235/70/16's A/T's for tires so I'm up one size from factor default.